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    ( II):

    -1a.

    - Interferon beta-1a

    .
    −1a, ( ). — 200 . / (1 30 −1, 6 . ). , 166 , . () .

    .
    - , , . , - , .. I , , 2',5'-, 2- .

    (, 2- .) 15–75 . 12 4–7 . 48 . −1 -, , .

    , −10 , . −1 ( ). −1. in vitro ( ) ( ) in vivo. 2 8% . , 12 15% .

    . . -, −1 , 100 , ( ). , , 2 , .

    , 100 , . , 3–5 , ( 2- ). .

    −1 .

    : / 60 max 45 / 3–15 , T1/2 — 10 ; / max — 30 /, — 3–18 , T1/2 — 8,6 . / 40%, / — 3 . , , .

    .
    ( 2 3 ).

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     |  |   | 
  • ( I):
  • ( I):
  • 2007 . 18,2%.
  • Solvay Pharma
  • 17 %
  • Teva Pharmaceutical Industries Active Biotech
  • 2007 . 18,2%.

    19.04.2011   

    18.04.2011  : -8, -68, -32, -20, -68,-5, -40, -50, -5, -10, -220(), ,  

    04.04.2011  -, .  

    19.04.2011   

    19.04.2011   

    19.04.2011  /.  

    COLORCOAT PRISMA
    LEWABRANE
    24 " "
    TOPYIELD
    BASF
    KEEP 32
    ""
    ?
    ˻:
    :
    -
    Ļ
    BASF 2012
    ?
    DIREVO
    -
    ,
    MAGNISENSE
    YOUPIG
    ߻
    :
    Ļ
    NATUPHOS
    +

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